Open AccessAdipose Stromal Cells Repair Pressure Ulcers in Both Young and Elderly Mice: Potential Role of Adipogenesis in Skin Repair
Author(s) -
Strong Amy L.,
Bowles Annie C.,
MacCrimmon Connor P.,
Frazier Trivia P.,
Lee Stephen J.,
Wu Xiying,
Katz Adam J.,
Gawronska-Kozak Barbara,
Bunnell Bruce A.,
Gimble Jeffrey M.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0235
Subject(s) - adipose tissue , medicine , mesenchymal stem cell , stromal cell , wound healing , stem cell , adipogenesis , surgery , pathology , biology , microbiology and biotechnology
This study uses a murine model to address the hypothesis that adipose‐derived stromal/stem cell (ASC) treatment would accelerate and enhance pressure ulcer repair. The results are consistent with clinical reports that fat grafting improved skin architecture in thermal injuries, thus setting the stage for clinical translation of autologous and/or allogeneic ASC treatment of pressure ulcers.