Open AccessComparative Study of Autologous Stromal Vascular Fraction and Adipose‐Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury
Author(s) -
You Dalsan,
Jang Myoung Jin,
Kim Bo Hyun,
Song Geehyun,
Lee Chunwoo,
Suh Nayoung,
Jeong In Gab,
Ahn Tai Young,
Kim Choung-Soo
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0161
Subject(s) - stromal vascular fraction , intracavernous injection , medicine , adipose tissue , erectile dysfunction , endocrinology , mean arterial pressure , von willebrand factor , urology , blood pressure , platelet , heart rate
The abilities of intracavernous injection of autologous stromal vascular fraction (SVF) and adipose‐derived stem cells (ADSCs) to facilitate recovery of erectile function in a rat model of cavernous nerve injury were compared. Intracavernous injection of SVF significantly improved erectile function compared with that in the control group, whereas the ADSC group showed marginally significant improvement. The increases in the smooth muscle/collagen ratio and von Willebrand factor expression were larger in the SVF group than in the ADSC group. Both cell types are equally effective in recovering penile erection, but SVF may be superior to ADSCs in terms of histomorphometric changes.