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pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of metha nol nd one of nine different buffers (60:40, v/v).  values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was pl otted against of each mobile phase. The inflection point of each sigmoidal curve represented of the compound. Using  in already known equations for the specific methan ol/buffer mixture, values were calculated. Obtained p Ka values for synthesized compounds were in a narrow range from 3.34–3.81 and p Ka for ibuprofen was 4.45. Predicted p Ka values for these compounds in SPARC software showed good correlation with experimental pKa values (R=0.8048).

Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography