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Recently, fasting flexibility for laboratory determination of lipid profile has been recommended. When triglycerides (TG) are above 400 mg/dl, the formula proposed by Martin et al. should be used to estimate the low-density lipoprotein cholesterol (LDL-C). However, this formula has not been evaluated in our population. Objectives: We evaluated the performance of Martin’s equation for LDL-C estimation compared to Cordova & Cordova and Friedewald formulas in a population of Southern Brazil. Methods: Sampling consisted of 10,664 Brazilian individuals (5,847 women) aged 1 to 93 years, with TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C directly measured. Results: Martin’s formula presented significantly higher LDL-C values in patients with TG < 300 mg/dl, underestimating values when TG > 400 mg/dl, even with negative values; and LDL-C values was also overestimated in all TC ranges, with greater standard deviation. It also presented a higher mean error in the stratified intervals, and a lower correlation coefficient. Conclusion: Martin’s equation is not accurate for estimating LDL-C in our sample, unless TG is between 300 and 400 mg/dl. We recommend using the Cordova & Cordova formula as an alternative to determine LDL-C when its direct measurement is not available, and not applying the Martin’s Formula indiscriminately to other populations before it is properly evaluated and compared with other available equations.

Martin’s, Friedewald’s and Cordova’s formulas compared to LDL-C directly measured in Southern Brazil