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1. Flavin mononucleotide inhibits the initiation and shortens the duration of convulsions caused by phenol. Flavin mononucleotide previously injected is more effective than when injected at the same time as phenol for the inhibition of phenol convulsions, and they are similarly effective in shortening the duration of phenol convulsions.2. A similar experiment was also carried out with flavin-adenine dinucleotide, and the results showed the same tendency. These results suggest that the riboflavin part of flavin nucleotide may be an active component in the above-mentioned effect.3. Since the dissociation constant of flavin mononucleotide and phenol complex was measured to be 0.12 moles per liter, it was considered that 1/6 of phenol formed the complex with flavin mononucleotide in this experiment. This may partly explain the effect of flavins on the phenol convulsion.

EFFECT OF FLAVINS ON CRAMP CAUSED BY PHENOL