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Objectives: In this study, it was aimed to compare effects of general anesthesia and spinal anesthesia on the immune system via serum cytokines interleukine 2 (IL-2), interleukine 4 (IL4), interleukine 6 (IL-6) in urologic cancer patients. Methods: Forty-four, ASA physical status I–II patient, who were scheduled for urooncologic surgery with spinal or general anesthesia enrolled to the study. Demographic parameters, heart rate and mean blood pressure values were recorded. Venous blood samples were taken at preoperative period and postoperatively 6th hours to determine IL-2, IL-4 and IL-6 levels. Results: There was no statistical significance between groups among heart rate and mean blood pressure values. There were no significant difference in preopera tive IL-2, IL-4, IL-6 and postoperative IL-2, IL-4 levels between groups, however postoperative IL-6 levels were significantly increased in general anesthesia group com pared with spinal anesthesia group (p<0.05).

Comparison of the effects of regional and general anesthesia on the immune system via cytokines in urooncologic surgery