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Massive osteolysis is an extremely rare disease associated with aggressive resorption of bone. It is usually indolent and progresses rapidly. However, the etiology of this disease remains to be elucidated. We describe a 25-year-old woman who presented with massive osteolysis of the maxilla and mandible accompanied by severe pain and paralysis of the mental nerve. We performed a partial maxillectomy and a mandibular segmentectomy in March 2005. Approximately 3 years after the operation, the bone lysis of the jaws resolved and the associated pain disappeared. There has been no evidence of recurrence.

A case of massive osteolysis of the jaws with sensory nerve abnormality