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Nicorandil is a potassium-channel activator used to treat angina pectoris in Japan since 1984. It is licensed and has been available in Europe since 1994. Oral ulceration induced by nicorandil was initially reported in France in 1997, and similar cases were reported in foreign countries. In Japan, only a few reports have described oral ulceration induced by nicorandil, and the mechanism of ulceration remains unclear. This paper presents three cases of severe oral ulceration caused by nicorandil. We review the relevant literature.

Three cases of severe tongue ulceration caused by nicorandil