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Plasma cell granuloma is a pseudotumor characterized by aggregation of plasma cells. It rarely occurs in the oral cavity. A case of plasma cell granuloma of the buccal mucosa in a 42-year-old woman is reported. She suffered from repeated bite wounds of the right buccal mucosa from 18 months previously, and a granulomatous lesion of this region, initially measuring 15×15mm, developed 15 months previously. The lesion came in contact with metal crowns. Inflammatory cell infiltration chiefly by plasma cells was recognized in the biopsy specimen of lesion. Polyclonality of plasma cells was revealed by immunohistochemical staining of kappa and lambda chains. The histopathological diagnosis was plasma cell granuloma. She had a history of metal allergy and a patch test for dental metal was positive. The stimulation index in the lymphocyte stimulation test by palladium was high. Dental metal allergy was thus suggested to be the main cause of this lesion. The metal crowns in contact with the lesion were removed. The lesion gradually disappeared. Since other region of the oral mucosa that were in contact with the metal crown appeared normal, this lesion was suggeted to be caused by local trauma, as well as metal allergy.

A case of plasma cell granuloma of the buccal mucosa probably caused by dental metal allergy.