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A case of eosinophilic granuloma occuring in the mandibular of a 6-years old boy was reported.In the histopathological examination of extirpated material, eosinocyte infiltrates and increased histiocytes in the connective tissue and Langerhans cell granules were observed by electronmicroscopy. Histiocytosis-X cells showed a positive reaction to S-100 protein by PAP method. These results suggested that the histiocyte of eosinophilic granuloma was derived from T-zone histiocyte.We performed both surgical therapy and combination chemotherapy of prednisolone and Vinblastin. No recurrence was observed in 2 years and 6 months follow up, but a long term follow up study at least for 5 years would be necessary for early detection and adequate treatment of recurrence.

Eosinophilic granuloma of mandible: a report of a case with histochemical and electric microscopical findings.