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After more than a decade of studying the chromatin remodeling, better view of the function mechanisms of the chromatin remodeling complexes has been developed. It was found that chromatin remodeling complexes facilitate transcription of genes by reducing the nucleosome density on specific genomic regions, such as enhancers and promoters, and increasing their affinity to activators and activator-binding complexes. Moreover, the importance of the chromatin remodeling complexes for transcriptional repression has been shown recently [1, 2]. Therefore chromatin remodeling complexes appear to be involved in nearly all aspects of transcription regulation [3].

SWI/SNF Chromatin Remodeling Complex Involved in RNA Polymerase II Elongation Process in Drosophila melanogaster