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It is noteworthy to consider that extensive bioavailability and bioequivalence studies are typically required before new drug therapies can be approved [1]. These studies include pharmacokinetic studies that take into account: 1) dosing, absorption, and elimination rates of the drug and its active metabolites, as well as 2) the potential effects of multiple doses, drug interactions, and the differences whether medications are taken with or without food. A major therapeutic factor that compounds the variations often seen from patient to patient is individual differences in absorption and elimination rates. This will also cause variations in the amount of drug that reaches the desired targeted tissue when used as a clinical therapy.

Localized Drug Delivery for Cardiothoracic Surgery