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From biopharmaceutical point of view, in vitro-in vivo correlation (IV-IVC) is a predictive mathematical treatment describing the relationship between an in vitro property of a dosage form (usually the rate or extent of drug release) and a relevant in vivo response (e.g. plasma or urine drug concentrations or amount of drug absorbed). IV-IVC is recommended by various regulatory bodies and mostly applicable to drug dosage forms for oral routes and sustained release products. It is a useful tool for drug dosage form development, because a successful correlation can assist in the selection of drug formulation with appropriate and acceptable dissolution criteria, and depending on its predictiveness, it can be used as a forecast or surrogate for further bioequivalence studies. There are different categories of IVIVC; A, B, C and D.

Correlation of in vitro Dissolution Profiles with in vivo Pharmacokinetic Parameters of Some Commercial Brands of Aspirin Tablets Marketed in Nigeria