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Fatigue may originate from peripheral or central causes, thus being “physical” or “cognitive” (mental) in nature. Some authors also put forward the concepts “primary” or “secondary” fatigue (DeLuca, 2005). It may be that the different dimensions of fatigue have different neurobiological and neurophysiological correlates (see also Chaudhuri and Behan, 2000; 2004). The big problem, however, is that in-depth analyses of different types of fatigue have yet to be performed.

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Long-Lasting Mental Fatigue After Recovery from Meningitis or Encephalitis - A Disabling Disorder Hypothetically Related to Dysfunction in the Supporting Systems of the Brain