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Adenylosuccinate lyase (ADSL) deficiency is a disease of purine metabolism which affects patients both bioche- micall and behaviorally. An obstacle of this purine nucleotide cycle(PNC) can be caused brain functional disorder and growth disorder. So ADSL deficiency, which is associated with sever mental retardation, autistic features and energy metabolism. This study was performed to identify SNP on ADSL gene in chicken. The nucleotides were observed as T to C (7724 th nucleotide), C to T nd nucleotide), G to T (10108 th nucleotide), A to T (10356 th nucleotide), G to A(10375 th nucleotide), A to C (10402 nd nucleotide), A to T (12716 th nucleotide), T to A (12717 th nucleotide), C to T (15491 st nucleotide), C to T (15542 nd nucleotide) and C to T (15550 th nucleotide). The nucleotide substitutions at 15542 nd and 15550 th (GeneBank accession no. AY665559) were found as missense mutation (alanine valine, proline serine, respectively). This study will be useful for farther researches for identi- fying association between these SNPs and energy metabolism in chicken. The C15550T SNP showed three genotypes, CC, CT, TT by digestion with the genotype TT had significantly faster the first lay day (150.0) than CT (162.0, P<0.05) and genotype TT (150.0, P<0.05) had significantly higher the egg production rate than CT (172.4, P<0.05). According to result of this study, a C15550T was found to have a significantly effect first lay day and mean egg production. It will be possible to use SNP marker on selecting chicken to improve important economic traits, which is the first lay day and mean egg production.

Identification of Novel Single Nucleotide Polymorphisms on ADSL Gene Using Economic Traits in Korean Native Chicken