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Tetanoz, Clostridium tetani tarafindan yara yerinden salinan tetanospazmin (ekzotoksin) isimli guclu bir norotoksin etkisiyle kontrol edilemeyen kas spazmlari ile seyreden bir hastaliktir. Tetanospazmin alfa motor noronlarin noromuskuler kavsagindan sinir sistemine girer. Toksin buradan retrograt transport ile noronal hucrelerin govdesine ulasir. Spinal kord veya beyin sapina gelen toksin, hucre disi bosluga ve buradan da presinaptik inhibitor hucrelere gecer. Bu hucreler transmitor olarak glisin ve GABA kullanmaktadir. Toksin tarafindan transmitor saliniminin engellenmeCiddi Bir Tetanoz Olgusunun Yogun Bakimda Takip ve Tedavisi Follow-up and Treatment of a Severe Tetanus Case in the Intensive Care Unit

Follow-up and treatment of a severe tetanus case in the intensive care unit