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A 67-year-old patient visited the hospital for the evaluation of pulmonary nodular lesions detected in his chest radiograph during an annual screening. He was asymptomatic and transbronchial tumor biopsy of the nodule in the right upper lobe revealed features of pulmonary sarcoma, which did not resemble any of the histolopathological categories of primary lung cancer. A positive immunological staining for both HMB-45 and Melan-A resulted in the final diagnosis of melanoma. It is important for a respiratory clinician to remind the possibility of a melanoma, when tumors cannot be histopathologically classified under any of the categories of primary lung cancer.

A case of multiple pulmonary nodules diagnosed as pulmonary melanoma without extra-pulmonary site