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Autologous fat injection laryngoplasty is a safe and useful management method for patients with unilateral vocal fold paralysis. In this study, autologous fat obtained by liposuction and used as injection material was investigated histologically. The harvested fat tissue from 13 patients who were undergoing injection laryngoplasty was examined by light and electron microscopy. The process of liposuction had not damaged the cell membranes and cytoplasm of the fat tissue. Each harvested fat cell was surrounded by a meshwork of fine reticular fibers. The size and density of fat cells were different from individual to individual. The diameter of the fat cells correlated with the body mass index of the subjects. Sparse and large fat cells tended not to be able to maintain graft volume. We examined 57 patients for voice function (maximum phonation time (MPT) , mean airflow rate (MFRc) , pitch perturbation quotient (PPQ) , amplitude perturbation quotient (APQ) , and normalized noise energy (NNEa) ) at least 6 months after they had underwent fat injection laryngoplasty. Voice function after surgery had improved significantly for all parameters. Post operative measurements relative to patient population were as follows: MPT below 10 seconds for 28%, MFRc above 250m1/sec for 11%, PPQ above 0.5% for 14%, APQ above 1.5% for 35% and NNEa above 20dB for 46%.

Fundament and Clinical Medicine for Fat Injection Laryngoplasty