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Few studies have evaluated the effect of pulmonary Langerhans cell histiocytosis on lung function in pregnancy and the appropriate mode of delivery. Case Series: Case 1 details a young multiparous female affected by pulmonary Langerhans cell histiocytosis with the need for baseline oxygen therapy outside of pregnancy and fetus with severe growth restriction requiring delivery at term by cesarean section. Case 2 includes a young multiparous female with pulmonary Langerhans cell histiocytosis with an uncomplicated pregnancy course and delivery at term by cesarean section. Conclusion: In patients with pulmonary Langerhans cell histiocytosis, lung function typically remains stable in pregnancy. Interstitial lung disease may affect birth weight. There may be a recommendation for delivery by cesarean section to reduce pneumothorax risk.

Stable lung function with pulmonary Langerhans cell histiocytosis in pregnancy