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ABS TRACT Objective: Positive surgical margins after radical prostatectomy is important due to increased risk of biochemical recurrence. Preoperative clinical stage, prostate specific antigen (PSA) value and the Gleason Score are the predictors of surgical margin status. In this study we aimed to assess the effects of preoperative variables on surgical margin positivity in patients with low or intermediate risk. Material and Methods: Preoperative clinical stage, PSA value, prostate volume and variables obtained from prostate biopsies of 73 patients who were grouped in low or intermediate risk according to D’Amico criteria (Clinical satge≤ T2b, PSA<10 ng/dl, Gleason Score ≤ 7) were compared with regard to surgical margin positivity status retrospectively. Results: The rate of the patients with positive surgical margins was 23.3%. The mean prostate volume was 84.91 ml±21.43 and 56.05 ml±18.42 in negative and positive surgical margin groups, respectively (p=0.001). While 14.6% of the patients with a PSA level <10 ng/dl had positive surgical margins, this rate was 34.4% in the patients with a PSA level of 10-20 ng/dl. (p=0.05). Increased numbers of positive cores in prostate biopsy were related with positive surgical margins (p=0.001). In multivariate analysis, only, prostate volumes less than 70 ml was found to be statistically significant (p=0.023). Conclusion: Smaller prostate volumes less than 70 ml. increase the risk of positive surgical margins in patients with low or intermediate risk.

journal of reconstructive urology

Assessment of Preoperative Predictive Factors for Positive Surgical Margins in Patients with Low or Intermediate Risk Prostate Cancer Who Underwent Retropubic Radical Prostatectomy