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ABS TRACT Objective: To evaluate the results of accelerated (9 mW/cm2) corneal crosslinking (CXL) in progressive keratoconus according to age groups. Material and Methods: Patients undergoing accelerated corneal CXL with hypo-osmolar riboflavin solution were included in the study. The patients were divided into two groups: Group 1 (<18 years, 41 eyes of 37 patients) and Group 2 (≥18 years, 47 eyes of 44 patients). Uncorrected and corrected distance visual acuity (UDVA, CDVA), refraction, topographic values and higher-order aberrations were evaluated in the preoperative period and postoperatively at months 1, 3 and 6. Results: In Group 1, a significant increase was detected in UDVA [0.25 logarithm of minimum angle of resolution (logMAR), p=0.035] and CDVA (0.19 logMAR, p=0.029), whereas there was no significant increase in Group 2 [UDVA (0.08 logMAR, p=0.375) and CDVA (0.12 logMAR, p=0.087)]. The maximum keratometry (Kmax) reduction was not significant [1.33 Diopter (D), p=0.141] in Group 1, whereas it was significant in Group 2 (1.48 D, p=0.002). The Kmax change between the two groups was similar (p=0.728). In both groups, refraction, elevations, astigmatism, spherical aberration (except Group 1), and trefoil reduction were insignificant and similar (p>0.05). Significant coma reduction was detected in the groups (p<0.05). However, the reduction in Group 2 was more apparent (p=0.025). Higher-Order Root Mean Square (HO-RMS) and total RMS reduction were significant and similar in both groups (p<0.05). Conclusion: VA improvement is better in the pediatric group than the adult group, while refraction, topographic and aberration (except coma) changes are similar after accelerated corneal CXL.

Accelerated Corneal Crosslinking Results with Respect to Age Groups