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46 orneal and conjunctival intraepithelial neoplasia (CCIN) is a premalignant lesion of the corneal epithelium and limbus and the most common tumor of the ocular surface.1 Generally it occurs in the interpalpebral fissure, usually at the region of the limbus, although it may be found elsewhere.2 The etiology of this disease is most likely multifactorial, involving such factors as age, ultraviolet light exposure, human papillomavirus, and human immunodeficiency virus. Management of these lesions includes wide local excision followed by supplemental cryotherapy, and topical chemotherapy with antineoplastic drugs. CCIN has been known to have a high recurrence rate after excision alone. Cryotherapy, radiation, Successful Treatment of Corneal and Conjunctival Intraepithelial Neoplasia with Topical Interferon Alfa-2b: Case Report