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Objective: Insulin- like growth factor-1 (IGF-1) regulates a number of cellular functions such as prolifera - tion and differentiation. On the other hand, insulin-like growth factor binding protein-3 (IGFBP-3) is a putative tumor suppressor and inhibits the proliferative activity of IGF-I. Therefore most studies report that IGF-I and IGFBP-3 may promote and inhibit tumor growth, respectively. In this study we aimed to evaluate the importance of IGF-1 and IGFBP- 3 in advanced stage non-small cell lung cancer (NSCLC) and to find out whether they contribute to clinical evaluations. Material and Methods: We measured the pretreatment serum levels of IGF-1 and IGFBP-3 in 80 men between July 2007 and June 2008 by chemiluminescent immunometric assay. Serum samples were obtained from 50 patients with in - operable advanced stage NSCLC at Dr. Suat Seren Pulmonary Diseases Hospital and 30 healthy controls at Izmir Tepecik Research Hospital. All 80 men had a smoking history of minimum 20 pack/years. Results: Contrary to the results of many reports, the serum IGF-1 levels were lower in the patients and the difference between the groups reached a sta - tistical significance (p=0.025). IGF-1/IGFBP-3 ratio was also significantly lower in lung cancer patients (p=0.016). The histological subtype of tumor was correlated with IGF-1 level (p=0.005). Conclusion: Our result showed that serum level of IGF-I/IGFBPs may be useful markers for diagnosing and identifying tumor subtypes in NSCLC. In addition, IGF- 1 and IGFBP-3 levels in serum might serve a clinical significance in patients with advanced stage NSCLC. However, fur - ther studies comprising more cases are needed to investigate the clinical significance of IGF-1 and IGFBP-3 in NSCLC.

türkiye klinikleri tıp bilimleri dergisi

Pretreatment Serum Levels of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein-3 in Men with Advanced Non-Small Cell Lung Cancer