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Objective: The purpose of this retrospective cohort study was to investigate how a premature rise in serum luteinizing hormone (LH) level affects pregnancy outcomes in patients with high progesterone (P) levels (≥1.5 ng/mL) on ovulation trigger day in GnRH antagonist/intracytoplasmic sperm injection cycles (ICSI). Materials and Methods: Between March 2010-July 2015, a total of 2.111 GnRH antagonist/ICSI cycles were conducted at Tepecik Education and Research Hospital, Gynecology and Obstetrics Clinic, In Vitro Fertilization Center. Serum LH levels were monitored during follicular phase and serum P levels were measured on the hCG-day. Basic demographic, hormonal and developmental data of embryos following oocyte retrieval and pregnancy outcome of patients were also monitored. Among all, 205 cycles matching inclusion criteria and with serum P levels ≥1.5 ng/mL on hCG day were included in the analysis. Results: Mean age (31.2±4.5 vs. 33.0±4.8, year) and body mass index (24.6±4,4 vs. 26.2±3.6, kg/m2), infertility reasons and baseline hormonal levels are similar in the normal vs. high LH level groups. Premature LH rise (>10 mIU/mL) was detected in 9 (4.39%) of the 205 antagonist cycles with high serum P levels (>1.5 ng/mL) on ovulation trigger day. The group with the premature LH rise had higher chemical, clinical, ongoing pregnancy and live birth rates (44.4% for all) than the group without premature LH rise (30.6%, 23.5%, 17.9% and 17.9%, respectively). However, the differences were not significant (p values were equal to 0.465, 0.226, 0.069 and 0.069 respectively). Additionally, logistic regression analysis did not find a statistically significant difference between the two groups in terms of all pregnancy rates. Conclusion: In conclusion, in GnRH antagonist/ICSI cycles with hCG-day serum P levels ≥1.5 ng/mL, there was no statistically significant difference between chemical, clinical, ongoing pregnancy and live birth rates among the groups with and without premature LH rise.

türkiye klinikleri jinekoloji obstetrik

Effect of Premature Luteinizing Hormone Rise on Pregnancy Outcomes in Patients with High Trigger Day Progesterone Levels in GnRH Antagonist In Vitro Fertilization Cycles