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ABS TRACT The human reproductive system is more sensitive than other species to functional disorders. Each organ in the system should function properly in the process of fertilization. Data of recent genetic studies suggest a critical role of multiple genes in various reproductive organs and tissues. Even though scrutinizing studies about all macroand microprocesses in fertility are yet being held, and the system is trying to be untangled, the pathophysiology of infertility remains an appealing subject to research, which encircles the known sieged by unknown. The extracellular matrix (ECM) is not only a structural support for the cells, but also is a functional mesh which has determining role in cellular shapes, behaviors, differentiation, proliferation, gene expressions, and their life cycles. Matricellular proteins are members of extracellular matrix which functions in regulation of cellular reactions, cell-to-cell and cell-matrix interactions via providing the interplay among structural macromolecules, growth factors, cytokines, and proteinases. A Disintegrin-like And Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteins are a group of zinc-dependent metalloproteinases responsible for degradation of ECM structures, which significantly act in many physiologic and pathologic processes. We aimed, in this review, to pose a broad view about the pathophysiology of infertility gathering the studies pertaining to matricellular proteins and ADAMTS enzymes which participate in the riddle of matrix breakdown and renewal.

Matricellular Proteins and Related ADAMTS Genes in Infertility