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Prostate cancer is the utmost communal type of cancer in adult men. Assessment of serum total prostate specific antigen (PSA) is broadly cast-off as a screening assistance in the prompt diagnosis of cancer of prostate. Irrespective of the prostate size or patient’s age, 25% cut off value is set or less free PSA level in percentage is suggested for cases with values of PSA amid 4.1 and 10 ng/ml; This helps in detecting prostate cancers in 95% of cases and prevent 20% of unnecessary biopsies. The greater the free PSA percentage, the less jeopardy of cancer. This analysis was designed to evaluate the incidence of prostate cancer in patients with a low percentage of free PSA. If the scale is found to be higher, aggressive strategies and early treatment can lead to good progress. Aim: To determine the frequency of prostate cancer in males with a low percentage of serum free PSA. Study Design: This is a descriptive, cross-sectional study lasting 6 months from July 2020 to December 2020 at the Urology Department of the Sindh Institute of Urology and Transplantation. Subject and method: 149 total individuals with symptoms of lower urinary tract were included in the research. All patients who came to the urology clinic (OPD); free PSA were examined with the same technique as the surgical patient and the result was recorded as proforma. Results: - The prostate cancer Incidence in males with decreased free serum PSA in percentage is noted in 128(85.91%) patients. Conclusions: Our study showed that prostate-specific free antigen plays an important role in the analysis of cancer of prostate. Keywords: Serum prostate specific antigen, Prostate cancer, percentage of free PSA

Frequency of Prostate Cancer in Men with Low Percent Free Prostate Specific Antigen in the Serum