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Aim:  To evaluate the effectiveness of Myo-inositol and D-chiro-Inositol combination therapy in improvement of Endocrine and clinical parameters in teenage girls affected by PCOS. Methods:  This Prospective Cohort study was conducted in the Department of Gynaecology &amp; Obstetrics, Avicenna Medical College and hospital after approval from Institutional  ethical committee from January 2021 to June 2021. We have enrolled 106 teenage girls from 13 to 19 years with PCOS. Baseline clinical, ultrasound and biochemical parameters were noted and assigned them into two treatment groups (A &amp; B) randomly. Group A was given MI plus DCI and Group B was given placebo for 6 months. Differences were analyzed in pretreatment and post treatment ultrasound findings and Clinical variable of BMI, Acne, hirsutism and menstrual irregularities. Biochemical parameters including LH:FSH ratio, 17-beta Estradiol and fasting glucose were also evaluated in both groups. Statistical Analysis was done using SPSS version 21. Results: A statistically significant improvement was observed in clinical &amp; Laboratory parameters in treatment group showing reduced LH:FSH ratio, fasting glucose and increased Estradiol levels along with decreased  BMI, Acne and hair growth and improved ultrasound parameters in same group as compared to placebo group.  Conclusion: The current study showed promising results of combined therapy with MI plus DCI for treatment and improvement of clinical and lab parameters in teenage girls affected with PCOs as compared to placebo. Keywords: PCOS, Myo-inositol, D-chiro-inositol, Hirsutism, Acne.

Role of Myo-inositol and D-Chiro-Inositol in Improvement of Endocrine and Clinical Parameters in Girls affected by PCOS