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A non invasive ultrasound technique has been proposed as a mean of detection of early fibrosis by measuring changes in the diameter of the hepatic inferior vena cava (IVC). Objectives: To determine the mean diameter of hepatic portion of inferior vena cava and mean reduction in its diameter by inspiration in normal and cirrhotic patients using USG. Study Design: Case control study. Methodology: This study (n=60) was conducted after ethical review committee’s (ERC) approval from April-October 2018 at Department of Radiology, Military Hospital Rawalpindi. Patients with stage 5 and 6 of cirrhosis were taken as cases. Controls had sonographically normal livers. The maximal diameter of IVC was measured during normal breathing first followed by a deep breath. Statistical analysis: Data was analyzed by SPSS, v-20. Parameters were measured by applying t-test with p≤0.05 as significant. Results: The IVC diameter during deep inspiration was 1.217±0.168 cm and 1.711±0.422 cm among controls and cirrhotic cases respectively (p= 0.00). The mean IVC diameter decrease was 1.02±0.25 cm and 0.03±0.02 cm by inspiration among controls and cases respectively having statistically significant p-value (&lt;0.05). Conclusion: We concluded that stiffness of the hepatic parenchyma have caused the physiological changes in the diameter of IVC enhanced by deep respiration. Thus, it can be used as a tool for evaluation of cirrhotic patients. Key Words: Cirrhosis, Hepatic Portion of Inferior Vena Cava, Liver and Sonography

pakistan journal of medical and health sciences

Comparing Diameter of Hepatic Portion of Inferior Vena Cava During Normal Breathing in Normal Individuals Versus Cirrhotic Patients: Case Control Study