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The Sechium edule fruit is traditionally proven to contain antiulcer. Thus, it is necessary to develop dosage formulations. An effervescent granule is chosen as an alternative form of drug delivery, considering its dosage preparation may apply simply within a short amount of time. This study aims to discover the composition of the mixture of citric acid, tartrate acid, and sodium bicarbonate met the physical test requirement for effervescent granule. Effervescent granules are made by wet granulation technique (the mixture of alkali-acid) by <25% of relative humidity on 20-25oC temperature. There are three effervescent granule formulas, consisting a different portions composition of citric acid, tartrate acid, and sodium bicarbonate: formula I = (2.5 :5:15); formula II = (2.25:4.5:16.88); and formula III = (2:4:18). Physical test on granules consists of flow rate test, moisture content, time of dissolution, pH and organoleptic. Following trials performed on Formulas I, II, and III of effervescent granule, the granules flow time of each formula are:1.48;1.53;1.48 seconds moisture content: 3.40; 3.62; 3.50%, time of solubility : 4.37; 4.25; 3.65 minutes, pH: 6.62; 6.54; 6.59, and likeness survey: (Colour=1.93; 1.90;2,0.Scent=2.0; 1.93; 2.07. Flavour=1.76; 2.06; 2.13). Those three formulas met the good physical test requirement, except on the moisture content. Formula III go the most preference on colour, scent and taste.

Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate