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In the paper, a fast level set for nuclei images is proposed. It is performed with a novel method, mainly combining idea of signed pressure force function with Legendre polynomials. The advantages of the proposed method are as follows. On the one hand, a controlled signed pressure force function based on 1-D Legendre polynomials (LPSPF) can stop the final contours at blurred and multiple objects edges, especially for nuclei images segmentation. On the other hand, we set multiple ball contour as initial contour to automatically detect the exterior and interior boundaries in the image. Ultimately, an improved edge stopping function is applied to fast and robustly capture the edge of multiple regions of interest (ROI). Experimental results demonstrate that our method is higher and faster accuracy than other models on nuclei images and other images with large size, or low-contrast.

A Fast Level Set Based on New Signed Pressure Force Function for Nuclei Images Segmentation