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Tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis has caused more deaths than other infectious diseases over the past 200 years. Granulomas are characteristic of mycobacterial infection. Doubling of Mycobacterium tuberculosis bacilli in any place will cause specific inflammation to form characteristic granulomas. Granulomas contains of different types of cells, but the main cellular component of the structure is macrophages. Macrophages are cells for the formation of granulomas and major cell types in most granulomas. One function of macrophages in granulomas is the production of anti-inflammatory cytokines IL-10. IL-10 can reduce inflammation and maintain homeostasis. This study aims to determine the effect of the addition of macrophages to levels of interleukin-10 (IL-10) in granuloma model in vitro. This type of research is true experimental with the object of research in the form of PBMC which comes from 1 healthy volunteer. Analysis using twoway ANNOVA with P <0.05, and tukey comparing for comparison. The results showed that without macrophage group with 1x105, 2x105, and 3x105 macrophage groups, the value of p = 0.3197 was greater than 0.05 (p> 0.05), so there was no significant difference. While the variation day in the treatment group obtained p = 0.2407 which showed no effect of macrophage addition to interleukin-10 (IL-10) level on granuloma model in vitro, with IL-10 concentration on the 1st day until the 5th day are low. There is no effect of adding macrophages to IL-10 levels in tuberculosis granuloma

The Effect of Macrophage Addition to Interleukin 10 (IL-10) in Tuberculosis Granuloma Model In Vitro