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There is an increasing evidence that psychological stress and depression trigger changes in various biochemical parameters in animals and human subjects. Chronic stress in rats, and psychosocial stress in humans, is implicated in the pathophysiology of mood and anxiety disorders.

annals of neurosciences

Investigations on light –induced stress model and on the role of phyllanthus amarus in attenuation of stress related depression-with focus on 5ht2a m-rna expression