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Multiple myeloma (MM) is a monoclonal neoplastic plasma cell characterized by the excessive proliferation of malignant plasma cells in the bone marrow. The bone marrow microenvironment is necessary for the survival and proliferation of MM cells. Within this microenvironment there is a complex cellular signaling involving multiple cytokines conferring survival, tumor development and resistance to chemotherapeutic agents. The purpose of this experimental work was to investigate 106 Milton Sérgio Bohatch Jr. et al. Publ. UEPG Biol. Health Sci., Ponta Grossa, v.16, n.2, p. 105-109, jul./dez. 2010 the secretion of cytokines (IL-6, TGF-B, VEGF and FGF-B) in a MM cell line (RPMI 8226). MM cells were cultured in culture fl asks containing RPMI 1640 supplemented with 10% Fetal Bovine Serum (FBS) and kept in an incubator CO2 tension to 5% and 37o C. Quantifi cation of cytokines and growth factors present in the cell culture supernatant of multiple myeloma was performed using the ELISA method. Cytokines measured in cell supernatants, especially IL-6 and VEGF, relate directly to the tumor microenvironment, promoting angiogenesis and signaling pathways activating anti-apoptotic, which provide the MM cells the necessary characteristics to survive and proliferate.

publicatio uepg. ciências biológicas e da saúde

QUANTIFICAÇÃO E ANÁLISE DOS FATORES DE CRESCIMENTO IL-6, TGF-B, VEGF E B-FGF NO SOBRENADANTE DE CULTURA DE MIELOMA MULTIPLO. UMA CORRELAÇÃO COM O MICROAMBIENTE TUMORAL