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Litter size is an important economic trait in the goat industry. Previous studies on the bone morphogenetic protein 15 ( BMP15 ) gene detected some single-nucleotide polymorphisms (SNPs) such as c.963A  &gt;  G that were associated with an increase in ovulation rate and litter size. The aim of this study was to conduct a meta-analysis on the effect of this polymorphism on litter size. We gathered and pooled data from five eligible published studies. To investigate the effect of c.963A  &gt;  G on litter size, we utilized four different genetic models assuming dominant ( GG    +    GA vs. AA ), recessive ( GG vs. GA    +    AA ), additive ( GG vs. AA ) and co-dominant ( GG    +    AA vs. GA ) model of inheritance. Data were analyzed under random-effects models based on the    I  2    value. Furthermore, sensitivity analysis was carried out to validate the stability of results. The results showed that the c.963A  &gt;  G polymorphism is associated with litter size when applying a dominant model (standardized mean difference (SMD) is 0.815, 95 % CI [0.170, 1.461],  P   value   =   0.013) and also with an additive model (SMD   =   0.755, 95 % CI [0.111, 1.400],  P   value   =   0.022). However, the effect of c.963A  &gt;  G polymorphism was not significant under recessive (SMD   =   0.186, 95 % CI [  -  0.195, 4.259],  P   value   =   0.339) and co-dominant (SMD   =     -  0.119, 95 % CI [  -  0.525, 0.288],  P   value   =   0.568) models. Sensitivity analysis demonstrated that dropping studies with wide confidence intervals affects overall results under the assumption of an additive model. The meta-analysis results revealed that the AA genotype could be positively connected with litter size in goats.

Meta-analysis of association between c.963A>G single-nucleotide polymorphism on BMP15 gene and litter size in goats