English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new approach to estimating the allele frequencies of lethal autosomal-recessivegenetic disorders was developed based on the gene dropping method. The method wastested in the complex pedigrees of 1 830 125 animals of the Austrian Brown Swisspopulation, where carriers for 4 genetic disorders were recorded. Trends of allelefrequencies of Spinal Dysmyelination and Spinal Muscular Atrophy increased whileWeaver decreased, but allele frequencies of Arachnomelia fluctuated between 2 and 3 %.The results were compared to the results from other methods. The results obtained fromprobability of gene origin were higher than the results from gene dropping in general,while the results from gene counting were lowest due to the fact that just a part of thepedigree information could be considered by the used program. The gene dropping andgene counting methods used here take lethal selection into account, while the programbased on probability of gene origin does not. Therefore, gene dropping and genecounting seem to be more appropriate for estimating the lethal allele frequency of lethalautosomal-recessive genetic disorders. Applying the gene dropping approach, one canobtain the distribution of allele frequencies and confidence intervals for the allelefrequency, which might be valuable for observing trends in active breeding populations

Estimating lethal allele frequencies in complex pedigrees via gene dropping approach using the example of Brown Swiss cattle