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The cardiac troponin complex, which is an important component of the contractileapparatus, is composed of the three subunits troponin I (TnI), troponin C (TnC) andtroponin T (TnT). Troponin I is the inhibitory subunit and consists of three isoformsencoded by TNNI1, TNNI2 and TNNI3 genes, respectively. Due to the different types ofcardiomyopathies caused by mutations in the TNNI3 gene and its fluorescence in situhybridization (FISH) mapping on bovine chromosome 18q26, which was shown to belinked to the recessively inherited bovine dilated cardiomyopathy (BDCMP), bovine TNNI3was considered as candidate gene for BDCMP. Real-time polymerase chain reaction (PCR) TNNI3 expression analysis resulted in asignificant difference between BDCMP affected and unaffected animals when normalizedto ACTB gene expression, but there was no significant difference in expression whennormalized to GAPDH. Northen blotting experiment was in agreement with the expressionanalysis and did not reveal a significant difference between the group of BDCMP affectedand unaffected animals. Sequencing of the bovine TNNI3 gene revealed a single nucleotidepolymorphism in intron 6 (c.378+315G>A), but this single nucleotide polymorphism(SNP)was present regardless of the BDCMP status. In summary our data provide evidenceto exclude the bovine TNNI3 gene as a candidate for BDCMP

Bovine cardiac troponin I gene (&lt;i&gt;TNNI3&lt;/i&gt;) as a candidate gene for bovine dilated cardiomyopathy

Bovine cardiac troponin I gene (<i>TNNI3</i>) as a candidate gene for bovine dilated cardiomyopathy