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Objective: Prion protein (PrP) expresion has previously been demonstrated in activated hepatic stellate cells (HSC), which play a key role in the development of liver fibrosis. In this study, we aimed to investigate the correlation between PrP expression and hepatic inflammation/fibrosis in patients with chronic viral hepatitis (CVH). Material and Methods: Liver specimens of 40 patients with CVH and 10 patients with metastatic liver disease having a normal liver architecture as a control group were evaluated. ThePrP staining index was calculated by counting PrP positive cells per microscopic field after immunostaining. Hepatic inflammatory activity and fibrosis scores were evaluated and compared with the number of PrP positive HSC. Results: Varying degrees of PrP expression were detected in histologic samples of the liver in patients with CVH, whereas no staining was observed in control specimens. It was also detected that the grade of inflammatory activity and stage of liver fibrosis were significantly correlated with PrP staining index (p=0.0001 for inflammation and p=0.005 for fibrosis). Conclusions: PrP is a good marker of activated HSC and correlates well with the inflammatory activity and stage of fibrosis in CVH. Turkish Baslik: Kronik Viral Hepatitde Prion Protein ve Karaciger Fibrozis Evresi Arasindaki Iliski Anahtar Kelimeler: Prion protein; viral hepatit; karaciger fibrozis; karaciger yildizsi hucre Amac: Prion protein (PrP) ekspresyonu karaciger fibrozisinde anahtar rol oynayan karaciger yildizsi hucrelerinde gosterilmistir. Bu calismada PrP ekspresyonu ile kronik viral hepatit hastalarindaki hepatik inflamasyon ve fibrosis arasindaki iliski arastirilmistir. Gerec ve Yontemler: 40 kronik viral hepatit hastasinin karaciger biyopsileri ve kontrol grubu olarak da 10 adet metastatik karaciger hastaligi nedeniyle opere olan ve normal karaciger dokusu bulunan hastalarin biyopsileri calismaya alindi. Immun boyama sonrasi PrP boyanma indeksi her mikroskopik alandaki PrP pozitif hucreler sayilarak hesaplandi. Hepatik inflamatuvar aktivite ve fibrozis skorlari ile PrP pozitif hucre sayisi arasindaki iliski karsilastirldi. Bulgular: Kronik viral hepatit hastalarinin karacigerlerinde degisik oranlarda PrP ekspresyonu saptanirken, kontrol grupta hic boyanma gozlenmedi. Ayrica PrP boyanma indeksi ile kronik hepatit inflamatuvar aktivite derecesi ve fibrozis evresi arasinda anlamli bir korelasyon bulundu (inflamasyon icin p=0.0001, fibrozis icin p=0.005). Sonuc: PrP aktivitesi karaciger yildizsi hucrelerinin bir belirleyicisidir. Ayrica PrP boyanmasinin kronik viral hepatit hastalarinda karaciger inflamasyonu ve fibrozisi ile iyi bir korelasyonu mevcuttur.

Association Of Prion Protein With The Stage Of Liver Fibrosis In Chronic Viral Hepatitis