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PT. Medica Indonesia was founded in 1969 and is one of the most significant ethical pharmaceutical companies in Indonesia. PT. Medica Indonesia, located in Cikarang, has a Pilot Plant Department that acts as a scale-up facility after lab scale to ensure that QTPP (Quality Target Product Profile) is consistently achieved on a pilot scale and a production scale. The high reject rate of 3.6% of the reject target of 0.5% for Tablet coating A products is a threat to the company because it can reduce productivity at PT. Medica Indonesia. Moreover, the Tablet coating A product is a mainstay product. In improving and improving the production line, it is necessary to identify the causes of waste. The integration of Lean Six Sigma using the DMAIC, VSM and VALSAT methods is an effective way to determine waste and the causes of waste. The analysis stage was carried out using the WRM and WAQ tools and determining recommendations for improvement using FMEA.

Lean Six sigma Integration to Reduce Waste in Tablet coating Production with DMAIC and VSM Approach in Production Lines of Manufacturing Companies