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The odanacatib (1) (Figure 1) is a specific inhibitor of cathepsin K acting as an antiresorptive agent that preserves bone-formation for the osteoporosis treatment. The clinical trial (phase III) of odanacatib (1) accomplished early due to the potencial efficacy, safety and favorable benefit-risk profile. 3 By considering the important role of odanacatib (1) for the osteoporosis treatment, the aim of this work is to develop new biocatalysts synthetic routes for building blocks of 1 by using microwave and continuous flow as strategy tools for reaction process optimization.

Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib