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Human herpesvirus includes eight species with distinct biological and clinical characteristics; HSV a universal human pathogen, is a neurotropic virus that has a linear double-stranded DNA and measured about 200 nm in diameter. HSV1 and HSV-2 are generally responsible for recurrent herpetic infection (RHI). Interleukin 17D is a pro-inflammatory cytokine, which is produced by a group of T helper cell known as T helper 17 cells. Interleukin-2 is a kind of cytokine signaling molecule within the immune system. It is protein that regulates the white blood cells activities (leukocytes, often lymphocytes) which are responsible for immunity. Molecular detection of HSV-1 and HSV-2 in lesion swab by real time PCR as well as immunological detection and comparison of IL-2 and IL-17D in saliva of healthy control subjects and recurrent herpetic infected patients. Sixty participant subjects participated in this clinical trial study include thirty patients infected with Herpes Simplex Virus with age range (6-48years) and thirty healthy control subjects; Thirty lesion swabs and (60) saliva samples were collected from those participant subjects. Real time PCR technique were used for detection of HSV-1, HSV-2 and ELISA test for IL-2 and IL-17D assessment. Both HSV-1 and HSV-2 was detected in lesion swabs from recurrent herpetic lesions, all patients were infected with HSV-1(100%), while (90%) of patients were infected with HSV-2. Interleukin 2 and IL-17D also detected in saliva samples of both HSV infected patients and control subjects. Mean interleukin-17D and IL-2 of patients with HSV infection was significantly higher than mean of these interleukins of healthy control subjects. Main age group with recurrent herpetic infection was (20-29 years) about 36.6% in the present study with male more than female patients (male to female ratio as 1.5:1), no significant differences were observed between patients with HSV infection and healthy controls regarding age (p=0.5) and gender (p=0.1). Patients with recurrent herpetic infection mostly infected with both HSV-1 and HSV-2 and only 10% of them were non-infected with HSV-2 with predominance of male than female. Saliva samples of recurrent herpetic infected patients revealed significant increase in IL-2 and IL-17D levels in comparison with healthy controls as assisted by ELISA test.

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MOLECULAR AND IMMUNOLOGICAL IDENTIFICATION OF BOTH HSV-1 AND HSV-2 IN RECURRENT HERPETIC INFECTED PATIENTS AMONG GROUPS OF PEOPLE IN BABYLON PROVINCE, IRAQ