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Management of patients with rheumatoid arthritis remains a major clinical problem but introduction of biologics significantly improved therapeutical strategy. Biologics reduce inflammation and its sequelae, including structural joint damage. Single direct comparative trials of biologics are only available, and indirect comparison methods are applied for evaluation of the biologics. Obtained results are not conclusive and are limited by several factors. Metaanalyses and indirect treatment comparison studies of biologic used for management of patients with rheumatoid arthritis are reviewed

How compare biologics applied for rheumatic disorders?