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Summary Objective: Amyloidosis is an important severe complication of rheumatoid arthritis (RA). The study was designed to evaluate poly morphism of the gene encoding serum amyloid A as well as Chlamy dia trachomatis infection as risk factors of development of amyloi dosis in RA patients. Material and methods: One-hundred and four patients with definite RA were investigated. The patients were divided into two groups, the AA-positive group (secondary amyloidosis confirmed by histopatho logical evaluation of the tissue sample) (45 patients), and the AA-neg ative group (59 patients). The polymorphism of SAA1 and occurrence of Chlamydia tra chomatis infection were assayed in all the patients. Results: No significant differences between the two patient groups in the -13T/C allele frequency were revealed. Therefore, the -13T allele is not obligatory for AA amyloidosis development in Belarusian patients with RA. Comparison of groups for genotype and three allele frequencies showed statistically significant dif ferences. The most notable differences were observed in SAA1 α/α genotype – χ2 = 31.1 ( p < 0.001). Forty-three of 45 AA-positive RA patients (96%) had SAA1 α/α genotype while only 32% AA-nega tive RA patients presented this genotype. A similar tendency was observed for allele α frequency: χ2 = 47.01 ( p < 0.001). Up to 84% of 45 AA-positive RA patients had concomitant Chla mydia trachomatis infection during the course of RA. In the AA-negative group association of RA and the infection was revealed in 10 (17%) of 59 patients only ( p < 0.004). Streszczenie

reumatologia

Amyloidosis in rheumatoid arthritis: role of serum amyloid A gene (SAA1) polymorphism and &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; infection in the Belarusian patient population