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An important factor in vascular wall alterations is degradation of elastic fiber major protein - elastin. As a result, elastin derived peptides (EDP) are found in circulation. Advanced glycation might also involve elastin, because it is a protein with slow metabolism. The aim of our study was to measure serum levels of glycated elastin derived peptides (AGE-EDP) of elastin in patients with type 2 diabetes mellitus (T2DM) and arterial hypertension (AH).

Clinical immunology Abnormal levels of age-elastin derived peptides in sera of diabetic patients with arterial hypertension