English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The diagnosis of eosinophilic esophagitis (EoE) is based on the clinical symptoms of esophageal dysfunction and histopathological findings of esophageal eosinophilia.1,2 In fact, the clinical, endoscopic, and histopathological characteristics of EoE and gastroesophageal reflux disease (GERD) overlap substantially, and differentiating the two can be difficult.1 Recently, Dellon et al1 suggested that tissue biomarkers of eosinophil activation or inflammation were useful for diagnosing EoE, especially for differentiating it from GERD.1 They performed immunohistochemistry for major basic protein (MBP), eotaxin-3, leukotriene A4 hydrolase (LTA4H) and leukotriene C4 synthase (LTC4S) in esophageal biopsy tissues from EoE and GERD patients and demonstrated that patients with EoE had much higher levels of MBP and eotaxin-3 in the esophageal epithelium than did GERD patients, while there were no differences in LTA4H and LTC4S.1 They evaluated the diagnostic utility of MBP and eotaxin-3 using receiver operating characteristic curves, and found that the combination of MBP and eotaxin-3 staining and the eosinophil numbers nearly completely predicted EoE status without considering other clinical, endoscopic or histopathological characteristics.1  The authors concluded that staining for MBP and eotaxin-3 might improve the current EoE diagnostic standards by adding a measure of eosinophil activity, especially for differentiating it from GERD.1

journal of neurogastroenterology and motility

Are Major Basic Protein, Eotaxin-3 and Leukotriene Enzyme Staining Useful for Diagnosing Eosinophilic Esophagitis? (Am J Gastroenterol 2012;107:1503-1511)