English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Arbaclofen placarbil (AP), previously designated as XP19986, is a novel transported prodrug of the active R-isomer of baclofen, which overcomes the pharmacokinetic limitations of racemic baclofen.1 AP is efficiently absorbed by high-capacity active transport pathways expressed throughout the gastrointestinal (GI) tract, and rapidly metabolized to release R-baclofen after the absorption.  This multicenter, randomized, double-blind, crossover study comparing single doses of AP with placebo was conducted to assess the efficacy and safety of AP for decreasing meal-induced reflux episodes in patients with gastroesophageal reflux disease (GERD).2  Different patients were enrolled at each of 4 escalating AP doses: 10, 20, 40 and 60 mg. A total of 50 patients were treated and the efficacy analysis included 44 patients who completed the protocol and had technically satisfactory impedance/pH data. There was a statistically significant decrease in reflux episodes over 12 hours after treatment with AP compared with placebo (p = 0.01). The mean ± SD number of reflux episodes over 12 hours after AP treatment was 50.5 ± 27.2, with a mean reduction of 10.4 ± 23.9 episodes (17%) compared with placebo (60.9 ± 35.3). Only acid reflux episodes were statistically decreased after treatment with AP. Heartburn events associated with reflux were reduced during treatment with AP compared with placebo (12.9 ± 11.9 vs 16.7 ± 18.2, p = 0.03). AP seemed to be the most efficacious in the 60 mg dose group, and was well tolerated at all dose levels.

Arbaclofen Placarbil Decreases Reflux With Good Tolerability in Patients With Gastroesophageal Reflux Disease (Am J Gastroenterol 2010;105:1266-1275)