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It has been reported that deep vein thrombosis and pulmonary embolism may occur after total arthroplasty in the lower extremities. This paper concerns the changes with time of TAT, and D-Dimer in 28 patients on drug therapy after total arthroplasty. We report two cases: one patient developed a pulmonary embolism just after surgery, while the other developed a deep vein thrombosis after four weeks. The changes with time of TAT and D-Dimer in these two patients were characteristic compared with patients free of symptoms.The measurement of TAT and D-Dimer is considered useful for the diagnosis of pulmonary embolism and deep vein thrombosis, and for determining the need for therapy.Preventive drug therapy may also be necessary for proplylaxis of pulmonary embolism occurring immediately after operation.

Transition of TAT, D-Dimer in Serum After Total Arthroplasty in Lower Extremities.