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Swain JE, Smith GD. Direct Effects of Leptin on Gonads, Gametes, and Embryos: Is Too Much a Bad Thing? ARBS Ann Rev Biomed Sci 2004;6:99-108. Originally discovered as a satiety factor and regulator of metabolism and fat deposition, emerging data suggest a role for leptin in regulation of reproductive function. The vast majority of research in this area focuses on the role of leptin in regulation of neuroendocrine function and the effects of the hormone on the hypothalamo-pituitary-gonadal axis. However, evidence exists indicating a direct role of leptin in regulation of the gonads, gametes and preimplantation embryos. The presence of leptin, its receptor, as well as studies demonstrating effects on function, development and activation of transcriptional and signal transduction pathways, all support the notion that leptin is directly affecting the ovary, testis, oocyte, spermatozoan and preimplantation embryo. These direct effects may be associated with reduced fertility. Key-words: leptin, oocyte, ovary, sperm, testis, embryo. Received: 09/09/04 Accepted: 15/11/04

<b>Direct Effects of Leptin on Gonads, Gametes, and Embryos: Is Too Much a Bad Thing?</b>