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3M.B.B.S Registrar Department of Medical Oncology Apollo Cancer Speciality Hospitals, Teynampet, Chennai, INDIA ABSTRACT AIM: This biochemical study aimed at evaluating the level of interleukin-1beta in patients with oral squamous cell carcinoma as a reflection of amount of bone destruction leading to periodontitis in comparison with the normal healthy individuals. MATERIAL & METHOD: The subjects were grouped under four major categories like chronic periodontits, chronic periodontitis with oral squamous cell carcinoma and squamous cell carcinoma alone and the control. Each group consisted of 10 subjects each. Unstimulated whole saliva was collected from each subject. IL-1 in saliva was measured by enzyme linked immunosorbent assay. RESULTS: In the present study, IL-1 was significantly more in patients with cancer and periodontitis than patients with only cancer. When compared with the normal subjects IL-1 value was significantly more in subjects with carcinoma (0.016). CONCLUSION: This study presents the first evidence of association between level of salivary biomarker interleukin 1 in subjects with periodontitis and in oral squamous cell carcinoma.

Interleukin-1 as a Marker of Periodontitis with Oral Carcinoma – A Biochemical Study