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A model is presented for routing optimization in the collection of perishable items, optimizing the start time of the route, considering service times and time-dependent sales losses. The costs associated with the maintenance of the refrigerated product are also considered, and the model is tested in a real case in a process of collection, unloading and sale of milk in a region in Colombia, verifying the usefulness of the model with the use of scenarios. key words: routing, pickup process, optimal start time, time dependent service time

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