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A straightforward approach to novel 2-dialkylamino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones synthesis is presented. The construction of these compounds was achieved by one-pot synthesis involving condensation of 2-aminopyridine or 2-aminopicolines with ethoxycarbonylisothiocianate, followed by amination of the thioureas, and finally thermal ring closure of resulting guanidines. This allowed access to the unreported title heterocycles. We described an efficient, facile, one-pot synthesis of a novel 2-dialkylamino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones in order to obtain a library of pyridotriazines which will be used as building blocks in medicinal chemistry.

international journal of current science research and review

A Facile Three-Steps, One-Pot Synthesis of Novel 2-Alkylamino and 2-Dialkylamino-4H-Pyrido[1,2-A][1,3,5] Triazin-4-Ones from 2-Aminopyridine and 2-Aminopicolines